REFERENCES

[1] Burton CV Spine 1978 Mar; 3(1): 24-30 Lumbosacral arachnoiditis

[2] Official Report 12 January 1998: Vol.304,c.152

[3] Burton CV, Internet article “Adhesive arachnoiditis: The Global Economic Liability” 1997

[4] Jayson MI, Keegan A, Million R, Tomlinson I Lancet 1984 Nov 24; 2(8413): 1186-7 A fibrinolytic defect in chronic back pain syndromes.

[5] Burton CV appearing in Neurological Surgery, Third Edition, Volume 4, pp: 2856-2865

[6] Koide J, Takada K, Sugiura M, Sekine H, Ito T, Saito K, Mori S, Takeuchi T, Uchida S, Abe T J Virol 1997 Mar; 71(3): 2478-2481 Spontaneous establishment of an Epstein-Barr virus-infected fibroblast line from the synovial tissue of a rheumatoid arthritis patient.

Wen S, Shimizu N, Yoshiyama H, Mizugaki Y, Shinozaki F, Takada K Am J Pathol 1996 Nov; 149(5): 1511-1517 Association of Epstein-Barr virus (EBV) with Sjogren's syndrome: differential EBV expression between epithelial cells and lymphocytes in salivary glands.

James JA, Kaufman KM, Farris AD, Taylor-Albert E, Lehman TJ, Harley JB J Clin Invest 1997 Dec 15; 00(12): 3019-26 An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus.

Dror Y, Blachar Y, Cohen P, Livni N, Rosenmann E, Ashkenazi A Am J Kidney Dis 1998 Nov; 32(5): 825-8 Systemic lupus erythematosus associated with acute Epstein-Barr virus infection.

[7] MacDonald SM, Rafnar T, Langdon J, Lichtenstein LM Science 1995 Aug 4; 269(5224): 688-90 Molecular identification of an IgE-dependent histamine-releasing factor.

[8] Benini A,Blanco J Schweitz Arch Neurol Psychiatr 1990;141(4):293-343 [Chronic fibroplastic leptomeningitis of the spinal cord and cauda equina]

[9] Tatara N Brain Nerve (Tokyo) 1992; 44(12): 1115-1125 Experimental Syringomyelia in rabbits and rats after localized spinal arachnoiditis.

[10] Johnson AJ, Burrows EH Br J Radiol 1978 Mar;51(603):196-202 Thecal deformity after lumbar myelography with iophendylate( Myodil) and meglumine iothalamate (Conray 280)

[11] Junck L, Marshall WH Ann Neurol 1983 May; 13(5): 469-84 Neurotoxicity of radiological contrast agents.

Skalpe IO Spine 1978 Mar; 3(1): 61-4 Adhesive arachnoiditis following lumbar myelography.

Suolanen J Ann Clin Res 1977 Aug; 9(4): 257-60 Adhesive arachnoiditis after lumbar myelography.

Johansen JG, Barthelemy CR, Haughton VM, Lipman BT, Ho KC AJNR Am J Neuroradiol 1984 Jan-Feb;5(1):97-9 Arachnoiditis from myelography and laminectomy in experimental animals

Tabor EN, Batzdorf U Neurosurgery 1996 Nov;39(5):1040-2 Thoracic spinal Pantopaque cyst and associated syrinx resulting in progressive spastic paraparesis: case report

[12] Skalpe IO Radiology 1976 Dec; 121(3 Pt. 1): 647-51 Adhesive arachnoiditis following lumbar radiculography with water-soluble contrast agents. A clinical report with special reference to metrizamide.

Jensen TS, Hein O J Neurol Neurosurg Psychiatry 1978 Feb; 41(2): 108-12 Intraspinal arachnoiditis and hydrocephalus after lumbar myelography using methylglucamine iocarmate.

Tanaka K, Nishiura I, Koyama T No Shinkei Geka 1987 Jan; 15(1): 89-93 Arachnoiditis ossificans after repeated myelographies and spinal operations--a case report and review of the literature].

Ward W, Matheson M, Gonski A Med J Aust 1976 Aug 28; 2(9): 333-5 Three cases of granulomatous arachnoiditis after myelography.

Haughton VM, Ho KC, Larson SJ, Unger GF, Correa-Paz F Radiology 1977 Jun; 123(3): 681-5 Experimental production of arachnoiditis with water-soluble myelographic media.

Haughton VM, Ho KC Radiology 1982 Jun; 143(3): 699-702 Arachnoid response to contrast media: a comparison of iophendylate and metrizamide in experimental animals.

Ahlgren P Invest Radiol 1980 Nov-Dec;15(6 Suppl): S264-6 Early and late side effects of water-soluble contrast media for myelography and cisternography: a short review.

Bohutova J, Vojir R, Kolar J, Grepl J Diagn Imaging 1979; 48(6): 320-5 Some unusual complications of myelography and lumbosacral radiculography.

Hansen EB, Fahrenkrug A, Praestholm J Br J Radiol 1978 May; 51(605): 321-7 Late meningeal effects of myelographic contrast media with special reference to metrizamide.

[13] Nakagawa H, Arita S, Kobayashi S, Ikoma Y, Oshino N Nippon Yakurigaku Zasshi 1989 Mar; 93(3): 187-96 [Neurotropic effects of non-ionic contrast media].

Obeid T, Yaqub B, Panayiotopoulos C, al-Jasser S, Shabaan A, Hawass NE Ann Neurol 1988 Oct; 24(4): 582-4 Absence status epilepticus with computed tomographic brain changes following metrizamide myelography.

Adams MD, Hopkins RM, Ferrendelli JA Invest Radiol 1988 Sep; 23 Suppl 1:S217-9 A rat EEG model for evaluating contrast media neurotoxicity.

Maly P, Bach-Gansmo T, Elmqvist D AJNR Am J Neuroradiol 1988 Sep; 9(5): 879-83 Risk of seizures after myelography: comparison of iohexol and metrizamide.

Llewellyn CG, Campbell DR, Quartey GR Can Assoc Radiol J 1988 Sep; 39(3): 230-1 Intracranial subdural hematoma complicating metrizamide myelography.

Kessler A, Radwan H, Kott E Harefuah 1988 May 1; 114(9): 435-7 [Transient encephalopathy following cervical myelography with metrizamide].

Kassicieh D, Drake ME Jr, Shuttleworth EC, Rammohan KW J Am Osteopath Assoc 1988 Mar; 88(3): 384-6 Conduction aphasia following metrizamide myelography.

Ahmed I, Pepple R, Jones RP Clin Electroencephalogr 1988 Jan; 19(1): 37-42 Absence status epilepticus resulting from metrizamide and omnipaque myelography.

[14] Wood KM Arguelles J Norenberg MD Reg Anaesth 1980 5:13-15 Degenerative lesions in rat sciatic nerves after local injections of methylprednisolone in aqueous solution.

[15] Nelson DA Arch Neurol 1988 Jul;45(7): 804-806 Dangers from methylprednisolone acetate therapy by intraspinal injection

[16] Mackinnon SE, Hudson AR Plast. Reconstr. Surg. 1982; 69: 482-489 Peripheral nerve injection injury with steroid agents.

[17] National Health and Medical Research Council (NHMRC) Australia, 1994 Epidural use of steroids in the management of back pain and sciatica of spinal origin.

[18] Byrod G, Olmarker K Spine 1995 20: 138-143 Rapid transport route between the epidural space and the intraneural capillaries of the nerve roots.

[19] Rosen CD, Kahanovitz N, Bernstein R, Viola K Clin Orthop 1988 Mar; (228):270-2 A retrospective analysis of the efficacy of epidural steroid injections.

[20] Andersen KH, Mosdal C Acta neurochir (Wien) 1987; 87(1-2): 52-3 Epidural application of cortico-steroids in low-back pain and sciatica.

[21] Cuckler JM, Bernini PA, Wiesel SW, Booth RE Jr, Rothman RH, Pickens GT J Bone Joint Surg[Am] 1985 Jan; 67(1):63-6 The use of epidural steroids in the treatment of lumbar radicular pain. A prospective, randomized, double-blind study.

[22] Carette S, Leclaire R, Marcoux S, Morin F, Blaise GA, St-Pierre A, Truchon R, Parent F, Levesque J, Bergeron V, Montminy P, Blanchette C N Engl J Med 1997 Jun 5; 336(23): 1634-40 Epidural corticosteroid injections for sciatica due to herniated nucleus pulposus.

[23] Ringsdal VS, Nielsen NA, Slot O, Kryger P Ugeskr Laeger 1997 Sep 15;159(38): 5653-7 [Epidural glucocorticoid injection in lumbago sciatica]

[24] Agency for Health Care Policy and Research (AHCPR); (Federal Government Agency) 1994 Clinical Practice Guideline No.14; Acute Low back problems in Adults: assessment and treatment.

[25] Vandermeulen E, Gogarten W, Van Aken H Anaesthetist 1997 Sep;46 Suppl 3: S179-S186 [Risks and complications following peridural anesthesia]

[26] Haisa t, Todo T, Mitsui I, Kondo T Neuro Med Chir(Tokyo) 1995 Feb;35(2):107-9 Lumbar adhesive arachnoiditis following attempted epidural anesthesia—case report

[27] Yuen EC, Layzer RB, Weitz SR, Olney RK Neurology 1995 Oct; 45(10): 1795-801 Neurological complications of lumbar epidural anesthesia and analgesia.

[28] Rocco AG, Philip JH, Boas RA, Scott D Reg Anesth 1997 Mar-Apr; 22(2):167-77 Epidural space as a Starling resistor and elevation of inflow resistance in a diseased epidural space.

[29] Hurst E, Weston J. Pathol Bacteriol 1955 38(70): 167-178 Adhesive Arachnoiditis and Vascular Blockage Caused by Detergents and other Chemical Irritants: An Experimental Study.

[30] Austin RT, Zuk JA J R Coll Surg Edinb 1989 Feb; 34(1): 30-2 Epidural adhesions after chymopapain chemonucleolysis.

[31] Moon MS, Kim I, Ok IY, Lee KW Int Orthop 1990;14(1):79-83 The response of nerve tissue to chymopapain

[32] Wehling P, Pak MA, Georgescu HI Acta Orthop Belg 1990; 56(3-4); 539-44 Intrathecal injection of a specific enzyme in rats as a model for chemically induced spinal cord injury.

[33] Kelly JM, Asbury AK, King JS J Neuropathol Exp neurol 1975 Sep; 34(5): 388-400 Neuropathological effects of intrathecal water.

[34] Moore DC, Hain RH JAMA 1954 156: 1050-1053 Importance of the perineural spaces in nerve blocking

[35] Malinovsky JM, Pinaud M Ann Fr Anesth Reanim 1996; 15(5): 647-58 [Neurotoxicity of intrathecally administered agents.]

[36] Sghirlanzoni A, Marazzi R, Pareyson D, Olivieri A, Bracchi M Anaesthesia 1989 Apr;44(4):317-21 Epidural anaesthesia and spinal arachnoiditis

Sklar EM, Quencer RM, Green BA, Montalvo BM, Post MJ Radiology 1991 Nov; 181(2): 549-554 Complications of epidural anesthesia: MR appearance of abnormalities.

[37] Burm AG Clin Pharmacokinet 1989 May; 16(5): 283-311 Clinical pharmacokinetics of epidural and spinal anaesthesia.

[38] Guyer DW, Wiltse LL, Eskay ML and Guyer BH. Spine 1989 Dec; 14(12): 1332-1341 The long range prognosis of arachnoiditis.

[39] Wilkinson HA Alternative therapies for the Failed Back Syndrome in The Adult Spine, JW Frymoyer ed.1991

[40] Jenik F, Tekle-Haimanot R, Hamory BH Paraplegia 1981; 19(3): 140-54 Non-traumatic adhesive arachnoiditis as a cause for spinal cord syndromes. Investigation of 507 patients.

[41] COFWA Survey, Martha Richardson 1999

[42] Brandt T Audiol Neurootol 1996 Jul-Aug; 1(4): 187-96 Cervical vertigo--reality or fiction?

[43] Bowsher D J Neurol Neurosurg Psychiatry 1996 Jul; 61(1): 62-9 Central pain: clinical and physiological characteristics.

[44] Ziegler MG, Ruiz-Ramon P, Shapiro MH Psychosom Med Jul-Aug; 55(4):339-46 Abnormal stress responses in patients with diseases affecting the sympathetic nervous system.

[45] Mathias CJ Hypertension 1991 Nov; 18(5 Suppl): III22-30 Role of sympathetic efferent nerves in blood pressure regulation and in hypertension.

[46] Khurana RK Neurology 1987 Jul; 37(7): 1221-4 Orthostatic hypotension-induced autonomic dysreflexia.

[47] Mathias CJ Hypertension 1991 Nov; 18(5 Suppl): III22-30 Role of sympathetic efferent nerves in blood pressure regulation and in hypertension.

Colachis SC 3d J Am Paraplegia Soc 1992 Jul; 15(3):171-86 Autonomic hyperreflexia with spinal cord injury.

[48] Auld AW Spine 1978 Mar; 3(1): 88-91 Chronic spinal arachnoiditis. A post-operative syndrome that may signal its onset.

[49] Bayer A, Thiel HJ, Zrenner E, Paulus W, Ried S, Schmidt D Nervenarzt 1995 Feb; 66(2): 89-96 [Disorders of color perception and increase glare sensitivity in phenytoin and carbamazepine therapy. Ocular side effects of anticonvulsants.

[50] Luoto S, Taimela S, Hurri H, Alaranta H Spine 1999 Feb 1; 24(3): 255-61 Mechanisms explaining the association between low back trouble and deficits in information processing. A controlled study with follow-up.

Kuhajda MC, Thorn BE, Klinger MRAnn Behav Med 1998 Winter; 20(1): 31-5 The effect of pain on memory for affective words.

[51] Torres D, Bauso Toselli L, Vecchi E, Leiguarda R, Doctorovich D, Merello M, Guevara J, Nogues M Medecina (B Aires) 1993;53(50):391-396 [Spinal arachnoiditis as a complication of peridural anesthesia]

Sklar EM, Quencer RM, Green BA, Montalvo BM, Post MJ Radiology 1991 Nov;18(2):549-554 Complications of epidural anesthesia: MR appearances of abnormalities

Nogues MA, Merello M, Leiguarda R, Guevara J, Figari A Eur Neurol 1992;32(2):99-101 Subarachnoid and intramedullary cysts secondary to epidural anesthesia for gynecological surgery

Tseng SH, Lin SM Clin Neurol Neurosurg 1997 Dec; 99(4): 256-8 Surgical treatment of thoracic arachnoiditis with multiple subarachnoid cysts caused by epidural anesthesia.

[52] Kendall BE, Valentine AR, Keis B, Neuroradiology 1982 Spinal arachnoid cysts: clinical and radiological correlation with prognosis.

[53] Kamada K, Iwasaki Y, Hida K, Abe H, Isu T No Shinkei Geka 1993 Feb;21(2):135-140 [Syringomyelia secondary to adhesive arachnoiditis: clinical profiles and efficacy of shunt operations]

[54] Caplan LR, Norohna AB, Amico LL J Neurol Neurosurg Psychiatry 1990 Feb; 53(2): 106-113 Syringomyelia and arachnoiditis.

[55] Tatara N Brain Nerve (Tokyo) 1992 44(12): 1115-1125 Experimental syringomyelia in rabbits and rats after localised spinal arachnoiditis.

[56] Kelley RE, Daroff RB, Sheremata WA, McCormick JR Arch Neurol 1980 Sep; 37(9): 588-9 Unusual effects of metrizamide lumbar myelography. Constellation of aseptic meningitis, arachnoiditis, communicating hydrocephalus, and Guillaine-Barre syndrome.

[57] Hendler NH, Bergson C, Morrison C Psychosomatics 1993 Dec; 34 (6): 49-501 Overlooked Physical Diagnoses in Chronic Pain Patients Involved in Litigation, Part 2.

[58] Perry, Barnes, Gronley Clin.Orthopaedics and Related Research 1988 Aug; 233:145-162 The Postpolio Syndrome-An Overuse Phenomenon

Perry, James, Fontaine, Mulroy, Downey Journal of Bone and Joint Surgery 1995 Aug;77-A(8):1148-1153 Findings in Post-Poliomyelitis Syndrome

[59] Burton CV, Internet publication( Institute for Low back and neck care website) ,April 1998

[60] Sjogren PM, Jensen NH, Jensen TS Pain 1994 Nov; 59(2): 313-6 Disappearance of morphine-induced hyperalgesia after discontinuing or substituting morphine with other opioid agonists.

[61] Ebert B et al J Pain Symptom Manage 1998 15(5):269-274 Dextropropoxyphene acts as a noncompetitive N-methyl-D-aspartate antagonist.

[62] McQuay HJ, Acta Anesthiol Scand 1997; 41 (1): 175-183 Opioid use in chronic pain

[63] Reimann W, Schlutz H, Selve N Anesth Analg 1999 Jan; 88(1): 141-5 The antinociceptive effects of morphine, desipramine, and serotonin and their combinations after intrathecal injection in the rat.

[64] James A. Stangl and John D. Loeser: Current Review of Pain 1997 1: 353-360. Intraspinal Opioid Infusion Therapy in the Treatment of Chronic Nonmalignant Pain [Review article]

[65] Paice JA, Penn RD, Shott S J Pain Symptom Manage 1996 Feb; 11(2): 71-80 Intraspinal morphine for chronic pain; a retrospective multicenter study.

[66] Bejjani GK, Karim NO, Tzortzidis F Surg Neurol 1997 Sep; 48(3): 288-91 Intrathecal granuloma after implantation of a morphine pump: case report and review of the literature.

Cabbell Kl, Taren JA, Sagher O Neurosurgery 1998 May; 42(5): 1176-80 Spinal cord compression by catheter granulomas in high-dose intrathecal morphine therapy: case report.

[67] Sjoberg M, Karlsson PA, Nordborg C, Wallgren A, Nitescu P, Appelgren L, Linder LE, Curelaru I Anesthesiology 1992 Feb; 76920; 173-86 Neuropathological findings after long-term intrathecal infusion of morphine and bupivicaine for treatment in cancer patients.

[68] Malinovsky JM, Lepage JY, Cozian A, Mussini JM, Pinaudt M, Souron R Anesthesiology 1993 Jan; 78(1):109-115 Is ketamine or its preservative responsible for neurotoxicity in the rabbit?

[69] Nordt SP Ann Pharmacother 1996 Oct;30(10):1179-80 Chlorobutanol toxicity;

DeChristoforo R, Corden BJ, Hood JC, Narang PK, Magrath IT Ann Intern Med 1983 Mar; 98(3): 335-6 High-dose morphine infusion complicated by chlorobutanol-induced somnolence.

[70] Malinovsky JM, Pinaud M Ann Fr Anesth Reanim 1996; 15(5): 647-58 [Neurotoxicity of intrathecally administered agents.]

[71] Kumar K, Nath R, Wyant GM J Neurosurg 1991 Sep; 75(3): 402-7 Treatment of chronic pain by epidural spinal cord stimulation: a 10-year experience.

[72] Meilman PW, Leibrock LG, Leong FT Clin J Pain 1989 Jun; 5(2): 189-93 Outcome of implanted spinal cord stimulation in the treatment of chronic pain: arachnoiditis versus single nerve root injury and mononeuropathy. Brief clinical note.

[73] Ronzoni G, De Vecchis M, Rizzotto A, Raschi R, Cuneo L Ann Urol (Paris) 1988; 22(1): 31-4 [Long-term results of spinal cord electrostimulation in the treatment of micturition disorders associated with neurogenic bladder].

[74] Kumar K, Nath R, Wyant GM J Neurosurg 1991 Sep; 75(3): 402-7 Treatment of chronic pain by epidural spinal cord stimulation: a 10-year experience.

[75] O’Connor M, Brighouse D, Glynn CJ Clin J Pain 1990 Sep; 6(3): 240-2 Unusual complications of the treatment of chronic spinal arachnoiditis.

[76] El-sayed A et al JAMA 1999; 281:818-823 Percutaneous Electrical Nerve Stimulation for Low Back Pain. A Randomised Crossover Study.

[77] Wheeler AH, Tucker CL AJPM 1997; 7(3): 92-97 Electrical muscle stimulation: Portable electrotherapy for neck and low back pain: patient satisfaction and self-care.

[78] Andalaro VJ, Monaghan DT, Rosenquist TH Pediatr Res 1998 Jan; 43(1): 1-7 Dextromethorphan and other N-methyl-D-aspartate receptor anatagonists are teratogenic in the avian model.

[79] Lohmann K, Prohl A, Schwartz E Gesundheitswesen 1996 Jun; 58(6): 322-31 [Multiple chemical sensitivity disorder in patients with neurotoxic illnesses].

[80] MacDonald SM, Rafnar T, Langdon J, Lichtenstein LM Science 1995 Aug 4; 269(5224): 688-90 Molecular identification of an IgE-dependent histamine-releasing factor.

[81]Ecoiffier EB, Tubery M, Adoue D, Durroux R, Juchet H, Ollier S, Arlet P

Presse Med 1997 Jun 21;26(21): 995-999 [Systemic manifestations of primary Gougerot-Sjogren syndrome. Nature and incidence apropos of 34 cases].

Tajima Y, Tsukishima E, Sudo K, Aimoto Y, Tashiro K No To Shinkei 1997 Sep; 49(9): 825-8 [A case of Sjogren syndrome associated with multiple mononeuritis and dysautonomia including bilateral tonic pupils].

Vetrugno R, Liguori R, Cevoli S, Salvi F, Montagna P Ital J Neurol Sci 1997 Oct; 18(5): 293-5 Adie’s tonic pupil as a manifestation of Sjogren’s syndrome.

Font J, Valls J, Cervera R, Pou A, Ingelmo M, Graus F Ann Rheum Dis 1990 Oct; 49(10): 775-8 Pure sensory neuropathy in patients with primary Sjogren’s syndrome: clinical, immunological, and electromyographic findings.

[82] Kumazawa K, Sobue G, Yamamoto K, Shimada N, Mitsuma T Rinsho Shinkeigaku 1993 Oct;33(10): 1059-65 [Autonomic dysfunction in sensory ataxic neuropathy with Sjogren’s syndrome]

[83] Nitsche A, Leiguarda RC, Maldonado Cocco JA, Lazaro MA, Garcia Morteo O Clin Rheumatol 1991 Mar; 10(1): 5-9 Neurological features in overlap syndrome.

[84] Tesavibul : Immunology Service, Massachusetts Eye & Ear Infirmary Harvard Medical School, Boston, MA Multiple Autoimmune Diseases :Internet source

[85] Kendall BE, Tatler GL Br J Radiol 1978 Feb; 51(602): 81-92 Radiological findings in neurosarcoidosis

[86] Sharma OP Chest 1997 Jul;112(1): 220-8 Neurosarcoidosis: a personal perspective based on the study of 37 patients

[87] Marinac JS Ann Pharmacother 1992 Jun; 26(6): 813-822 Drug- and chemical-induced aseptic meningitis: a review of the literature.

[88] Ribiero C, Reis FC Acta Med Port 1998 Jan:11(1): 59-65 [Adhesive lumbar arachnoiditis]

[89] Batzdorf U, Klekamp J, Johnson JP J Neurosurg 1998 Sep;89(3): 382-8 A critical appraisal of syrinx cavity shunting procedures

[90] Klekamp J, Batzdorf U, Samii M, Bothe HW J Neurosurg 1997 Feb; 86(2): 233-40 Treatment of syringomyelia associated with arachnoid scarring caused by arachnoiditis or trauma.

Table of Contents

Introduction
THE SCALE OF THE PROBLEM
ARACHNOIDITIS OR EPIDURAL FIBROSIS?
NOMENCLATURE
THE INFLAMMATORY NATURE OF ADHESIVE ARACHNOIDITIS
PATHOLOGY
CLASSIFICATION
CAUSES
THE IATROGENIC ASPECT OF ADHESIVE ARACHNOIDITIS
PRESERVATIVES IN SPINAL INJECTIONS
PROGNOSIS
THE SYNDROMIC NATURE OF SYMPTOMS IN ADHESIVE ARACHNOIDITIS (Warning: LONG)
COMPLICATIONS OF ADHESIVE ARACHNOIDITIS
DIFFERENTIAL DIAGNOSIS
CLINICAL ASSESSMENT
DIAGNOSTIC TESTS
TREATMENT OPTIONS (Warning: LONG)
MULTIPLE CHEMICAL SENSITIVITY
LOOKING TO THE FUTURE
APPENDIX I: AUTOIMMUNE ASPECTS
APPENDIX II: SYRINGOMYELIA
ADDENDUM - May 2000
REFERENCES